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Showing posts from February, 2026

More on The Microbiome

  The Microbiome: A New Mission for Metabolism A few years ago, a diagnosis of follicular lymphoma forced a pivot. I stopped looking at longevity as a "self-help" abstraction and started looking at it through the lens of a mission: how does the body actually maintain itself under pressure? That search led me to the gut microbiome—a trillion-member team that acts less like a digestive aid and more like a primary metabolic organ. Recent research has effectively deprecated the "calories in, calories out" model. It turns out our microbes are the ones actually pulling the levers on insulin sensitivity, inflammation, and energy storage. The Appendix: The Gut’s "Safe House" For decades, the appendix was dismissed as a vestigial organ—an evolutionary "legacy system" that only caused trouble. We now know it serves a critical purpose as a biological "safe house." Think of it...